Occurrence of RNA post-transcriptional modifications in plant viruses and viroids and their correlation with structural and functional features.

ABSTRACT: Post-transcriptional modifications of RNA bases are widespread across all the tree of life and have been linked to RNA maturation, stability, and molecular interactions. RNA modifications have been extensively described in endogenous eukaryotic mRNAs, however, little is known about the presence of RNA modifications in plant viral and subviral RNAs. Here, we used a computational approach to infer RNA modifications in plant-pathogenic viruses and viroids using high-throughput annotation of modified ribonucleotides (HAMR), a software that predicts modified ribonucleotides using high-throughput RNA sequencing data. We analyzed datasets from representative members of different plant viruses and viroids and compared them to plant-endogenous mRNAs. Our approach was able to predict potential RNA c

SUBMITTER: Marquez-Molins J 

PROVIDER: S-EPMC10194119 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature