Understanding the role of Ca²⁺ via transient receptor potential (TRP) channel in viral infection: Implications in developing future antiviral strategies.

ABSTRACT: Transient receptor potential (TRP) channels are a superfamily of cation-specific permeable channels primarily conducting Ca²⁺ions across various membranes of the cell. The perturbation of the Ca²⁺ homeostasis is the hallmark of viral infection. Viruses hijack the host cell Ca²⁺ signaling, employing tailored Ca²⁺ requirements via TRP channels to meet their own cellular demands. This review summarizes the importance of Ca²⁺ across diverse viruses based on the Baltimore classification and focuses on the associated role of Ca²⁺-conducting TRP channels in viral pathophysiology. More emphasis has been given to the role of the TRP channel in viral life-cycle events such as viral fusion, viral entry, viral replication, virion matura

SUBMITTER: Kumar PS 

PROVIDER: S-EPMC10194134 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature