Do people with hereditary cancer syndromes inform their at-risk relatives? A systematic review and meta-analysis.

ABSTRACT:

Purpose

To evaluate rates of familial disclosure of hereditary cancer syndrome information.

Methods

A systematic review and meta-analysis was conducted in accordance with PRISMA guidelines (PROSPERO no.: CRD42020134276). Key electronic databases were searched to identify studies evaluating hereditary cancer syndrome cascade relative disclosure. Eligible studies were subjected to meta-analysis.

Results

Thirty-four studies met inclusion criteria. Among 11,711 included relatives, 70% (95% CI 60 - 78%) were informed of their risk of carrying a cancer-associated pathogenic variant; of 2,875 relatives informed of their risk who were evaluated for uptake of cascade testing, 43% (95% CI 27 - 61%) completed testing. Rates of disclosure were higher among female vs male relative

SUBMITTER: Ahsan MD 

PROVIDER: S-EPMC10194207 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature