Identification, comprehensive characterization, and comparative genomics of the HERV-K(HML8) integrations in the human genome.

ABSTRACT: Around 8% of the human genome is composed by Human Endogenous Retroviruses (HERVs), ancient viral sequences inherited from the primate germ line after their infection by now extinct retroviruses. Given the still underexplored physiological and pathological roles of HERVs, it is fundamental to increase our information about the genomic composition of the different groups, to lay reliable foundation for functional studies. Among HERVs, the most characterized elements belong to the beta-like superfamily HERV-K, comprising 10 groups (HML1-10) with HML2 being the most recent and studied one. Among HMLs, the HML8 group is the only one still lacking a comprehensive genomic description. In the present work, we investigated HML8 sequences' distribution in the human genome (GRCh38/hg38), identifying

SUBMITTER: Scognamiglio S 

PROVIDER: S-EPMC10194239 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature