The role of the DE and EF loop of BKPyV VP1 in the serological cross-reactivity between subtypes.

ABSTRACT: BK virus (BKPyV) is a causative agent of BKPyV-associated nephropathy and graft rejections in kidney transplant patients. It establishes persistent infection in the kidneys, which can lead to reactivation in an immunosuppressed state or transmission to kidney recipients. Complications in the case of donor-derived infections can be caused by differences between the four known BKPyV subtypes, as prior infection with one subtype does not guarantee protection against de novo infection with other subtypes. The recipient and donor pretransplant serotyping is not routinely performed since simple ELISA tests employing antigens derived from the major viral capsid protein 1 (VP1) are hindered by the high cross-reactivity of anti-VP1 antibodies against all subtypes. Identifying subtype-specific epito

SUBMITTER: Hejtmankova A 

PROVIDER: S-EPMC10194259 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature