High antigenic diversity of serotype 1 infectious bursal disease virus revealed by antigenic cartography.

ABSTRACT: The antigenic characterization of IBDV, a virus that causes an immunosuppressive disease in young chickens, has been historically addressed using cross virus neutralization (VN) assay and antigen-capture enzyme-linked immunosorbent (AC-ELISA). However, VN assay has been usually carried out either in specific antibody negative embryonated eggs, for non-cell culture adapted strains, which is tedious, or on chicken embryo fibroblasts (CEF), which requires virus adaptation to cell culture. AC-ELISA has provided crucial information about IBDV antigenicity, but this information is limited to the epitopes included in the tested panel with a lack of information of overall antigenic view. The present work aimed at overcoming those technical limitations and providing an extensive antigenic landscape

SUBMITTER: Cubas-Gaona LL 

PROVIDER: S-EPMC10194283 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature