Paternal phthalate exposure-elicited offspring metabolic disorders are associated with altered sperm small RNAs in mice.

ABSTRACT: Exposure to ubiquitous plastic-associated endocrine disrupting chemicals (EDCs) is associated with the increased risk of many chronic diseases. For example, phthalate exposure is associated with cardiometabolic mortality in humans, with societal costs ∼ $39 billion/year or more. We recently demonstrated that several widely used plastic-associated EDCs increase cardiometabolic disease in appropriate mouse models. In addition to affecting adult health, parental exposure to EDCs has also been shown to cause metabolic disorders, including obesity and diabetes, in the offspring. While most studies have focused on the impact of maternal EDC exposure on the offspring's health, little is known about the effects of paternal EDC exposure. In the current study, we investigated the adverse impact of p

SUBMITTER: Liu J 

PROVIDER: S-EPMC10194346 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature