PKR-like ER kinase (PERK) Haplotypes Are Associated with Depressive Symptoms in People with HIV.

ABSTRACT:

Background

Depression is a debilitating and difficult-to-treat condition in people with HIV (PWH) despite viral suppression on antiretroviral therapy (ART). Depression is associated with activation of the PKR-like ER kinase (PERK) pathway, which regulates protein synthesis in response to metabolic stress. We evaluated common PERK haplotypes that influence PERK expression in relation to depressed mood in PWH.

Methods

PWH from 6 research centers were enrolled in the study. Genotyping was conducted using targeted sequencing with TaqMan. The major PERK haplotypes A, B, and D were identified. Depressive symptom severity was assessed using the Beck Depression Inventory-II (BDI-II). Covariates including genetically-defined ancestry, demographics, HIV disease/treatment parameters an

SUBMITTER: Haddadi S 

PROVIDER: S-EPMC10194542 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature