Hypertrophic cardiomyopathy caused by a heterozygous variant in TTR gene: A case report.

ABSTRACT:

Rationale

We report a rare case of hypertrophic cardiomyopathy (HCM) caused by a heterozygous variant in TTR gene.

Patient concerns

The proband had been vomiting without obvious inducement since the age of 27, accompanied by the expulsion of stomach contents. At the age of 28, she began to suddenly syncope.

Diagnosis

Cardiac magnetic resonance showed thickening of the right ventricular lateral wall and ventricular septum. The left ventricular diastolic function was limited. Targeted Sanger sequencing validates the presence of mutation p.Leu75Pro in TTR gene.

Interventions and outcomes

After admission to hospital for syncope, she was given metoprolol tablets 25 mg bid, spironolactone tablets 20 mg qd, and trimetazidine 20 mg tid. Her symptoms improved after taki

SUBMITTER: Yuan H 

PROVIDER: S-EPMC10194678 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature