Recent progress in experimental studies on the catalytic mechanism of cytochrome c oxidase.

ABSTRACT: Cytochrome c oxidase (CcO) reduces molecular oxygen (O₂) to water, coupled with a proton pump from the N-side to the P-side, by receiving four electrons sequentially from the P-side to the O₂-reduction site-including Fe_a3 and Cu_B-via the two low potential metal sites; Cu_A and Fe_a. The catalytic cycle includes six intermediates as follows, R (Fe_a3 ²⁺, Cu_B ¹⁺, Tyr244OH), A (Fe_a3 ²⁺-O₂, Cu_B ¹⁺, Tyr244OH), P_m (Fe_a3 ⁴⁺ = O^2-, Cu_B ²⁺-OH^-, Tyr244O•), F (Fe_a3 ⁴⁺ = O^2-, Cu_B</

SUBMITTER: Shimada A 

PROVIDER: S-EPMC10194837 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature