DDX43 mRNA expression and protein levels in relation to clinicopathological profile of breast cancer.

ABSTRACT:

Background

Breast cancer (BC) is the most often diagnosed cancer in women globally. Cancer cells appear to rely heavily on RNA helicases. DDX43 is one of DEAD- box RNA helicase family members. But, the relationship between clinicopathological, prognostic significance in different BC subtypes and DDX43 expression remains unclear. Therefore, the purpose of this study was to assess the clinicopathological significance of DDX43 protein and mRNA expression in different BC subtypes.

Materials and methods

A total of 80 females newly diagnosed with BC and 20 control females that were age-matched were recruited for this study. DDX43 protein levels were measured by ELISA technique. We used a real-time polymerase chain reaction quantification (real-time PCR) to measure the levels of DD

SUBMITTER: Amer NN 

PROVIDER: S-EPMC10194936 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature