Ontology highlight
ABSTRACT:
SUBMITTER: Gupta A
PROVIDER: S-EPMC10195009 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Gupta Aaron A Kao Kevin S KS Yamin Rachel R Oren Deena A DA Goldgur Yehuda Y Du Jonathan J Lollar Pete P Sundberg Eric J EJ Ravetch Jeffrey V JV
Nature communications 20230518 1
Immunoglobulin G (IgG) antibodies contain a complex N-glycan embedded in the hydrophobic pocket between its heavy chain protomers. This glycan contributes to the structural organization of the Fc domain and determines its specificity for Fcγ receptors, thereby dictating distinct cellular responses. The variable construction of this glycan structure leads to highly-related, but non-equivalent glycoproteins known as glycoforms. We previously reported synthetic nanobodies that distinguish IgG glyco ...[more]