Development of a neonatal Gottingen Minipig model for dose precision in perinatal asphyxia: technical opportunities, challenges, and potential further steps.

ABSTRACT: Animal models provide useful information on mechanisms in human disease conditions, but also on exploring (patho)physiological factors affecting pharmacokinetics, safety, and efficacy of drugs in development. Also, in pediatric patients, nonclinical data can be critical for better understanding the disease conditions and developing new drug therapies in this age category. For perinatal asphyxia (PA), a condition defined by oxygen deprivation in the perinatal period and possibly resulting in hypoxic ischemic encephalopathy (HIE) or even death, therapeutic hypothermia (TH) together with symptomatic drug therapy, is the standard approach to reduce death and permanent brain damage in these patients. The impact of the systemic hypoxia during PA and/or TH on drug disposition is largely unknown a

SUBMITTER: Stroe MS 

PROVIDER: S-EPMC10195037 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature