Regression Models for Understanding COVID-19 Epidemic Dynamics With Incomplete Data.

ABSTRACT: Modeling infectious disease dynamics has been critical throughout the COVID-19 pandemic. Of particular interest are the incidence, prevalence, and effective reproductive number (Rt). Estimating these quantities is challenging due to under-ascertainment, unreliable reporting, and time lags between infection, onset, and testing. We propose a Multilevel Epidemic Regression Model to Account for Incomplete Data (MERMAID) to jointly estimate Rt, ascertainment rates, incidence, and prevalence over time in one or multiple regions. Specifically, MERMAID allows for a flexible regression model of Rt that can incorporate geographic and time-varying covariates. To account for under-ascertainment, we (a) model the ascertainment probability over time as a function of testing metrics and (b) jointly model

SUBMITTER: Quick C 

PROVIDER: S-EPMC10195108 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature