Developing an Evolutionary Baseline Model for Humans: Jointly Inferring Purifying Selection with Population History.

ABSTRACT: Building evolutionarily appropriate baseline models for natural populations is not only important for answering fundamental questions in population genetics-including quantifying the relative contributions of adaptive versus nonadaptive processes-but also essential for identifying candidate loci experiencing relatively rare and episodic forms of selection (e.g., positive or balancing selection). Here, a baseline model was developed for a human population of West African ancestry, the Yoruba, comprising processes constantly operating on the genome (i.e., purifying and background selection, population size changes, recombination rate heterogeneity, and gene conversion). Specifically, to perform joint inference of selective effects with demography, an approximate Bayesian approach was employe

SUBMITTER: Johri P 

PROVIDER: S-EPMC10195113 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature