Dietary nitrate supplementation increases diaphragm peak power in old mice.

ABSTRACT:

Key points

Respiratory muscle function declines with ageing, contributing to breathing complications in the elderly. Here we report greater in vitro respiratory muscle contractile function in old mice receiving supplemental NaNO₃ for 14 days compared with age-matched controls. Myofibrillar protein phosphorylation, which enhances contractile function, did not change in our study - a finding inconsistent with the hypothesis that this post-translational modification is a mechanism for dietary nitrate to improve muscle contractile function. Nitrate supplementation did not change the abundance of calcium-handling proteins in the diaphragm of old mice, in contrast with findings from the limb muscles of young mice in previous studies. Our findings suggest that nitrate supplemen

SUBMITTER: Kumar RA 

PROVIDER: S-EPMC10195135 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature