Adipose-derived stem cells show hepatic differentiation potential and therapeutic effect in rats with acute liver failure.

ABSTRACT: Hepatocyte transplantation contributes to the repair of liver damage, but hepatocyte resources are limited, making it difficult for this to become a routine treatment. Previous studies have confirmed that mesenchymal stem cells (MSCs) can be induced to differentiate into hepatocyte-like cells (HLCs) by adding different cytokine combinations in vitro, and they then play some roles of hepatocytes. Our previous studies found that the differentiation ability of stem cells is closely related to the origin of the tissue. To identify the mesenchymal stem cells that are most suitable for hepatic differentiation and the treatment of liver failure, we use a three-phase induction process in which human adipose-derived stem cells (hADSCs) and umbilical cord mesenchymal stem cells (hUCMSCs) are

SUBMITTER: Jin Y 

PROVIDER: S-EPMC10195146 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature