Expression pattern and prognostic value of key regulators for N7-methylguanosine RNA modification in prostate cancer.

ABSTRACT: Alterations in the regulators of RNA methylation modifications, such as N7-methylguanosine (m7G), have been implicated in a variety of diseases. Therefore, the analysis and identification of disease-related m7G modification regulators will accelerate advances in understanding disease pathogenesis. However, the implications of alterations in the regulators of m7G modifications remain poorly understood in prostate adenocarcinoma. In the present study, we analyze the expression patterns of 29 m7G RNA modification regulators in prostate adenocarcinoma using The Cancer Genome Atlas (TCGA) and perform consistent clustering analysis of differentially expressed genes (DEGs). We find that 18 m7G-related genes are differentially expressed in tumor and normal tissues. In different cluster subgroups,

SUBMITTER: Zhai Q 

PROVIDER: S-EPMC10195147 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature