Anti-apoptotic genes and non-coding RNAs are potential outcome predictors for ulcerative colitis.

ABSTRACT: Due to the lack of clinical, immunologic, genetic, and laboratory markers to predict remission in ulcerative colitis (UC) without relapse, there is no clear recommendation regarding withdrawal of therapy. Therefore, this study was to investigate if transcriptional analysis together with Cox survival analysis might be able to reveal molecular markers that are specific for remission duration and outcome. Mucosal biopsies from patients in remission with active treatment-naïve UC and healthy control subjects underwent whole-transcriptome RNA-seq. Principal component analysis (PCA) and Cox proportional hazards regression analysis were applied to the remission data concerning duration and status of patients. A randomly chosen remission sample set was used for validation of the applied methods an

SUBMITTER: Meng W 

PROVIDER: S-EPMC10195737 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature