Long-term dietary nitrate supplementation slows the progression of established atherosclerosis in ApoE^-/- mice fed a high fat diet.

ABSTRACT:

Background and aims

Atherosclerosis is associated with a reduction in the bioavailability and/or bioactivity of endogenous nitric oxide (NO). Dietary nitrate has been proposed as an alternate source when endogenous NO production is reduced. Our previous study demonstrated a protective effect of dietary nitrate on the development of atherosclerosis in the apoE^-/- mouse model. However most patients do not present clinically until well after the disease is established. The aims of this study were to determine whether chronic dietary nitrate supplementation can prevent or reverse the progression of atherosclerosis after disease is already established, as well as to explore the underlying mechanism of these cardiovascular protective effects.

Methods

60 apoE^-/-

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10195750 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature