Developing OCHROdb, a comprehensive quality checked database of open chromatin regions from sequencing data.

ABSTRACT: International consortia, including ENCODE, Roadmap Epigenomics, Genomics of Gene Regulation and Blueprint Epigenome have made large-scale datasets of open chromatin regions publicly available. While these datasets are extremely useful for studying mechanisms of gene regulation in disease and cell development, they only identify open chromatin regions in individual samples. A uniform comparison of accessibility of the same regulatory sites across multiple samples is necessary to correlate open chromatin accessibility and expression of target genes across matched cell types. Additionally, although replicate samples are available for majority of cell types, a comprehensive replication-based quality checking of individual regulatory sites is still lacking. We have integrated 828 DNase-I hypers

SUBMITTER: Shooshtari P 

PROVIDER: S-EPMC10195780 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature