An organ-on-chip device with integrated charge sensors and recording microelectrodes.

ABSTRACT: Continuous monitoring of tissue microphysiology is a key enabling feature of the organ-on-chip (OoC) approach for in vitro drug screening and disease modeling. Integrated sensing units are particularly convenient for microenvironmental monitoring. However, sensitive in vitro and real-time measurements are challenging due to the inherently small size of OoC devices, the characteristics of commonly used materials, and external hardware setups required to support the sensing units. Here we propose a silicon-polymer hybrid OoC device that encompasses transparency and biocompatibility of polymers at the sensing area, and has the inherently superior electrical characteristics and ability to house active electronics of silicon. This multi-modal device includes two sensing units. The first unit co

SUBMITTER: Aydogmus H 

PROVIDER: S-EPMC10195821 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature