Bioenergetic Evaluation of Muscle Fatigue in Murine Tongue.

ABSTRACT: Muscle fatigue is the diminution of force required for a particular action over time. Fatigue may be particularly pronounced in aging muscles, including those used for swallowing actions. Because risk for swallowing impairment (dysphagia) increases with aging, the contribution of muscle fatigue to age-related dysphagia is an emerging area of interest. The use of animal models, such as mice and rats (murine models) allows experimental paradigms for studying the relationship between muscle fatigue and swallowing function with a high degree of biological precision that is not possible in human studies. The goal of this article is to review basic experimental approaches to the study of murine tongue muscle fatigue related to dysphagia. Traditionally, murine muscle fatigue has been studied in l

SUBMITTER: Glass TJ 

PROVIDER: S-EPMC10195920 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature