Temporal transcriptional control of neural induction in human induced pluripotent stem cells.

ABSTRACT:

Introduction

Neural induction of human induced pluripotent stem cells represents a critical switch in cell state during which pluripotency is lost and commitment to a neural lineage is initiated. Although many of the key transcription factors involved in neural induction are known, we know little of the temporal and causal relationships that are required for this state transition.

Methods

Here, we have carried out a longitudinal analysis of the transcriptome of human iPSCs undergoing neural induction. Using the temporal relationships between the changing profile of key transcription factors and subsequent changes in their target gene expression profiles, we have identified distinct functional modules operative throughout neural induction.

Results

In addition to module

SUBMITTER: Gupta S 

PROVIDER: S-EPMC10195998 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature