TANK shapes an immunosuppressive microenvironment and predicts prognosis and therapeutic response in glioma.

ABSTRACT:

Background

Glioma, the most prevalent malignant intracranial tumor, poses a significant threat to patients due to its high morbidity and mortality rates, but its prognostic indicators remain inaccurate. Although TRAF-associated NF-kB activator (TANK) interacts and cross-regulates with cytokines and microenvironmental immune cells, it is unclear whether TANK plays a role in the immunologically heterogeneous gliomas.

Methods

TANK mRNA expression patterns in public databases were analyzed, and qPCR and IHC were performed in an in-house cohort to confirm the clinical significance of TANK. Then, we systematically evaluated the relationship between TANK expression and immune characteristics in the glioma microenvironment. Additionally, we evaluated the ability of TANK to predict t

SUBMITTER: Li S 

PROVIDER: S-EPMC10196049 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature