Cortical superficial siderosis, hematoma volume, and outcomes after intracerebral hemorrhage: a mediation analysis.

ABSTRACT:

Background

Previous studies have shown that cortical superficial siderosis (cSS) can increase hematoma volume and predict poor outcomes following primary intracerebral hemorrhage (ICH).

Objective

We aimed to determine whether a large hematoma volume was the essential factor contributing to worse outcomes of cSS.

Methods

Patients with spontaneous ICH underwent a CT scan within 48 h after ictus. Evaluation of cSS was performed using magnetic resonance imaging (MRI) within 7 days. The 90-day outcome was assessed using the modified Rankin Scale (mRS). In addition, we investigated the correlation between cSS, hematoma volume, and 90-day outcomes using multivariate regression and mediation analyses.

Results

Among the 673 patients with ICH [mean (SD) age, 61 (13) year

SUBMITTER: Jin YJ 

PROVIDER: S-EPMC10196120 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature