Functional connectivity of the cerebellar vermis in bipolar disorder and associations with mood.

ABSTRACT:

Purpose

Studies of the neural underpinnings of bipolar type I disorder have focused on the emotional control network. However, there is also growing evidence for cerebellar involvement, including abnormal structure, function, and metabolism. Here, we sought to assess functional connectivity of the cerebellar vermis with the cerebrum in bipolar disorder and to assess whether connectivity might depend on mood.

Methods

This cross-sectional study enrolled 128 participants with bipolar type I disorder and 83 control comparison participants who completed a 3 T magnetic resonance imaging (MRI) study, which included anatomical as well as resting state Blood Oxygenation Level Dependent (BOLD) imaging. Functional connectivity of the cerebellar vermis to all other brain regions was ass

SUBMITTER: Saleem A 

PROVIDER: S-EPMC10196126 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature