Implications of gut microbiota dysbiosis and fecal metabolite changes in psychologically stressed mice.

ABSTRACT:

Introduction

Psychological stress can induce affective disorders. Gut microbiota plays a vital role in emotional function regulation; however, the association between gut microbiota and psychological stress is poorly understood. We investigated effects of psychological stress on the gut microbiome and fecal metabolites and assessed the relationship between affective disorder behavior and altered fecal microbiota.

Methods

A psychological stress model was established in C57BL/6J mice using a communication box. Sucrose preference test, forced swim test, and open field test helped assess anxiety- and depression-like behaviors. Fecal microbiota transplantation (FMT) was conducted using fecal samples from stressed and non-stressed mice. Moreover, 16S rRNA gene sequencing and untar

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10196128 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature