Mechanisms of action of monoclonal antibodies in oncology integrated in IMGT/mAb-DB.

ABSTRACT:

Background

Cancer cells activate different immune checkpoint (IC) pathways in order to evade immunosurveillance. Immunotherapies involving ICs either block or stimulate these pathways and enhance the efficiency of the immune system to recognize and attack cancer cells. In this way, the development of monoclonal antibodies (mAbs) targeting ICs has significant success in cancer treatment. Recently, a systematic description of the mechanisms of action (MOA) of the mAbs has been introduced in IMGT/mAb-DB, the IMGT® database dedicated to mAbs for therapeutic applications. The characterization of these antibodies provides a comprehensive understanding of how mAbs work in cancer.

Methods

In depth biocuration taking advantage of the abundant literature data as well as amino acid seq

SUBMITTER: Manso T 

PROVIDER: S-EPMC10196129 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature