Epigenetically altered macrophages promote development of diabetes-associated atherosclerosis.

ABSTRACT:

Background

Atherosclerosis (AS) risk is elevated in diabetic patients, but the underlying mechanism such as involvement of epigenetic control of foam macrophages remains unclear. We have previously shown the importance of immune regulation on endothelial cells to AS development in diabetes. In this study, we examined the hypothesis that diabetes may promote AS through modification of the epigenetic status of macrophages.

Methods

We employed the Laser Capture Microdissection (LCM) method to evaluate the expression levels of key epigenetic regulators in both endothelial cells and macrophages at the AS lesions of patients. We then assessed the correlation between the significantly altered epigenetic regulator and serum levels of low-density Lipoprotein (LDL), triglycerides (TRI

SUBMITTER: Huang D 

PROVIDER: S-EPMC10196132 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature