Plasma lipidomics of primary biliary cholangitis and its comparison with Sjogren's syndrome.

ABSTRACT:

Background

Abnormal lipid metabolism is common in patients with primary biliary cholangitis (PBC). PBC and Sjögren's syndrome (SS) frequently coexist in clinical practice; however, the lipid characteristics of both diseases are unknown. Therefore, we aimed to analyze the plasma lipid profiles of both diseases.

Methods

Plasma samples from 60 PBC patients, 30 SS patients, and 30 healthy controls (HC) were collected, and untargeted lipidomics was performed using ultrahigh-performance liquid chromatography high-resolution mass spectrometry. Potential lipid biomarkers were screened through an orthogonal projection to latent structure discriminant analysis and further evaluated using receiver operating characteristic (ROC) analysis.

Results

A total of 115 lipids were differ

SUBMITTER: Li H 

PROVIDER: S-EPMC10196160 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature