Leucine-rich alpha-2 glycoprotein as a potential biomarker for large vessel vasculitides.

ABSTRACT:

Objectives

Serum levels of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) have been used as useful biomarkers for reflecting the activity of large vessel vasculitides (LVV). However, a novel biomarker that could have a complementary role to these markers is still required. In this retrospective observational study, we investigated whether leucine-rich α-2 glycoprotein (LRG), a known biomarker in several inflammatory diseases, could be a novel biomarker for LVVs.

Methods

49 eligible patients with Takayasu arteritis (TAK) or giant cell arteritis (GCA) whose serum was preserved in our laboratory were enrolled. The concentrations of LRG were measured with an enzyme-linked immunosorbent assay. The clinical course was reviewed retrospectively from their medical

SUBMITTER: Umezawa N 

PROVIDER: S-EPMC10196172 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature