Pathogenicity and molecular characteristics of fowl adenovirus serotype 4 with moderate virulence in Guangxi Province, China.

ABSTRACT: The GX2020-019 strain of fowl adenovirus serotype 4 (FAdV-4) was isolated from the liver of chickens with hydropericardium hepatitis syndrome in Guangxi Province, China, and was purified by plaque assay three times. Pathogenicity studies showed that GX2020-019 can cause typical FAdV-4 pathology, such as hydropericardium syndrome and liver yellowing and swelling. Four-week-old specific pathogen-free (SPF) chickens inoculated with the virus at doses of 10³ median tissue culture infectious dose (TCID₅₀), 10⁴ TCID₅₀, 10⁵ TCID₅₀, 10⁶ TCID₅₀, and 10⁷ TCID₅₀ had mortality rates of 0, 20, 60, 100, and 100%, respectively, which were lower than those of chickens inoculated with other highly

SUBMITTER: Wei Y 

PROVIDER: S-EPMC10196193 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature