Prognostic immune markers identifying patients with severe COVID-19 who respond to tocilizumab.

ABSTRACT:

Introduction

A growing number of evidences suggest that the combination of hyperinflammation, dysregulated T and B cell response and cytokine storm play a major role in the immunopathogenesis of severe COVID-19. IL-6 is one of the main pro-inflammatory cytokines and its levels are increased during SARS-CoV-2 infection. Several observational and randomized studies demonstrated that tocilizumab, an IL-6R blocker, improves survival in critically ill patients both in infectious disease and intensive care units. However, despite transforming the treatment options for COVID-19, IL-6R inhibition is still ineffective in a fraction of patients.

Methods

In the present study, we investigated the impact of two doses of tocilizumab in patients with severe COVID-19 who responded or not to

SUBMITTER: De Biasi S 

PROVIDER: S-EPMC10196248 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature