Transcriptomic responses in the blood and sputum of cigarette smokers compared to e-cigarette vapers.

ABSTRACT:

Rationale

Electronic (e)-cigarettes are popular among youth and cigarette smokers attempting to quit. Studies to date have focused on the utility of e-cigarettes as a smoking cessation tool, but the biological effects are largely unknown.

Objectives

To identify transcriptomic differences in the blood and sputum of e-cigarette users compared to conventional cigarettes smokers and healthy controls and describe biological pathways affected by these tobacco products.

Methods

Cross-sectional analysis of whole blood and sputum RNA-sequencing data from 8 smokers, 9 e-cigarette users (e-cigs) and 4 controls. Weighted gene co-network analysis (WGCNA) identified gene module associations. Ingenuity Pathway Analysis (IPA) identified canonical pathways associated with tobacco prod

SUBMITTER: Perez MF 

PROVIDER: S-EPMC10196320 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature