Differential effects of high dose omega-3 fatty acids on metabolism and inflammation in patients with obesity: eicosapentaenoic and docosahexaenoic acid supplementation.

ABSTRACT:

Background

Obesity is complicated by low-grade chronic inflammation characterised by increases in inflammatory proteins and cells in peripheral blood. It has been known that omega-3 fatty acids (FA) like eicosapentaenoic (EPA) and docosahexaenoic (DHA) could modulate the inflammatory process and improve metabolic markers.

Objective

This study aimed to determine the effect of high-dose omega-3 FA on metabolic and inflammatory markers among patients with obesity and healthy volunteers.

Methods

This prospective study included 12 women with obesity (body mass index [BMI] ≥ 35.0 kg/m²) and 12 healthy women (BMI < 24.0 kg/m²) who were supplemented with a dose of 4.8 g/day (3.2 g EPA plus 1.6 g DHA) for 3 months followed by no treatment for 1 month. Pla

SUBMITTER: Borja-Magno A 

PROVIDER: S-EPMC10196397 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature