Cell-level systems biology model to study inflammatory bowel diseases and their treatment options.

ABSTRACT: To help understand the complex and therapeutically challenging inflammatory bowel diseases (IBDs), we developed a systems biology model of the intestinal immune system that is able to describe main aspects of IBD and different treatment modalities thereof. The model, including key cell types and processes of the mucosal immune response, compiles a large amount of isolated experimental findings from literature into a larger context and allows for simulations of different inflammation scenarios based on the underlying data and assumptions. In the context of a large and diverse virtual IBD population, we characterized the patients based on their phenotype (in contrast to healthy individuals, they developed persistent inflammation after a trigger event) rather than on a priori assumptions on p

SUBMITTER: Stubler S 

PROVIDER: S-EPMC10196411 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature