Biased computation of probability of target attainment for antimicrobial drugs.

ABSTRACT: The medical literature is replete with articles in which there is confusion between "free concentration" and "unbound fraction" (f_u ), which is the ratio of free to total plasma concentration. The lack of clarity in distinguishing between these two terms has led to biased computations, erroneous interpretations, and misleading recommendations. The problems are highlighted in this paper, taking the example of calculation of Probability of Target Attainment (PTA). This metric is used to propose pharmacokinetic/pharmacodynamic (PK/PD) breakpoints required for the interpretation of Antimicrobial Susceptibility Testing. Based on Monte Carlo simulations of the PK/PD index, area under the unbound concentration time curve/minimum inhibitory concentration (fAUC/MIC), computation of PTA f

SUBMITTER: Toutain PL 

PROVIDER: S-EPMC10196429 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature