Major depression-related factor NEGR1 controls salivary secretion in mouse submandibular glands.

ABSTRACT: Salivary gland cells, which secrete water in response to neuronal stimulation, are closely connected to other neurons. Transcriptomic studies show that salivary glands also express some proteins responsible for neuronal function. However, the physiological functions of these common neuro-exocrine factors in salivary glands are largely unknown. Here, we studied the function of Neuronal growth regulator 1 (NEGR1) in the salivary gland cells. NEGR1 was also expressed in mouse and human salivary glands. The structure of salivary glands of Negr1 knockout (KO) mice was normal. Negr1 KO mice showed tempered carbachol- or thapsigargin-induced intracellular Ca²⁺ increases and store-operated Ca²⁺ entry. Of interest, the activity of the large-conductance Ca^2+<

SUBMITTER: Lee J 

PROVIDER: S-EPMC10196562 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature