Gut Microbes and Circulating Cytokines in Preterm Infants with Growth Failure.

ABSTRACT:

Background

Growth failure (GF) is a multifactorial problem in preterm infants. The intestinal microbiome and inflammation may contribute to GF.

Objectives

This study's objective was to compare the gut microbiome and plasma cytokines in preterm infants with and without GF.

Methods

This was a prospective cohort study of infants with birth weights of <1750 g. Infants with a weight or length z-score change from birth to discharge or death that was less than or equal to -0.8 (GF group) were compared with infants without GF [control (CON) group]. The primary outcome was the gut microbiome (at weeks 1-4 of age), assessed by 16S rRNA gene sequencing using Deseq2. Secondary outcomes included inferred metagenomic function and plasma cytokines. Phylogenetic Investigation of Comm

SUBMITTER: Strobel KM 

PROVIDER: S-EPMC10196572 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature