Genome-wide association study (GWAS) of circulating vitamin D outcomes among individuals of African ancestry.

ABSTRACT:

Background

Vitamin D deficiency is more common among African-ancestry individuals and may be associated with adverse health outcomes. Vitamin D binding protein (VDBP) regulates concentrations of biologically active vitamin D.

Objective

We conducted genome-wide association study (GWAS) of VDBP and 25-hydroxyvitamin D among African-ancestry individuals.

Methods

Data were collected from 2,602 African American adults from the Southern Community Cohort Study (SCCS) and 6,934 African- or Caribbean-ancestry adults from the UK Biobank. Serum VDBP concentrations were available only in the SCCS and were measured by using the Polyclonal Human VDBP ELISA kit. Serum 25-hydroxyvitamin D concentrations for both study samples were measured by using Diasorin Liason, a chemiluminescent

SUBMITTER: Parlato LA 

PROVIDER: S-EPMC10196601 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature