Circulating thrifty microRNA is related to insulin sensitivity, adiposity, and energy metabolism in adults with overweight and obesity: the POUNDS Lost trial.

ABSTRACT:

Background

MicroRNA 128-1 (miR-128-1) was recently linked to the evolutionary adaptation to famine and identified as a thrifty microRNA that controls energy expenditure, contributing to obesity and impaired glucose metabolism.

Objectives

We investigated whether circulating miR-128-1-5p and its temporal changes in response to weight-loss diet interventions were related to regulating insulin resistance, adiposity, and energy expenditure in adults with overweight and obesity. We also examined whether habitual physical activity (PA) and different macronutrient intakes modified associations of changes in miR-128-1-5p with improved metabolic outcomes.

Methods

This study included 495 adults who consumed weight-loss diets with different macronutrient intakes. Circulating leve

SUBMITTER: Heianza Y 

PROVIDER: S-EPMC10196610 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature