Identification of anoikis-related subtypes and development of risk stratification system in skin cutaneous melanoma.

ABSTRACT:

Background

Anoikis, a form of apoptosis induced by cell detachment, plays a key role in cancer metastasis. However, the potential roles of anoikis-related genes (ARGs) in assessing the prognosis of skin cutaneous melanoma (SKCM) and the tumor microenvironment (TME) remain unclear.

Methods

The data from TCGA corresponding to transcriptomic expression patterns for patients with SKCM were downloaded and utilized to screen distinct molecular subtypes by a non-negative matrix factorization algorithm. The prognostic signature was constructed by least absolute shrinkage and selection operator (LASSO) Cox regression and was validated in SKCM patients from the GEO cohort. Moreover, the relationship of the ARG_score with prognosis, tumor-infiltrating immune cells, gene mutation, micro

SUBMITTER: Tian J 

PROVIDER: S-EPMC10196614 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature