Evaluation of triple negative breast cancer with heterogeneous immune infiltration.

ABSTRACT:

Introduction

Tumor infiltrating lymphocytes (TILs) are known to be a prognostic and predictive biomarker in breast cancer, particularly in triple negative breast cancer (TNBC) patients. International guidelines have been proposed to evaluate them in the clinical setting as a continuous variable, without a clear defined cut-off. However, there are scenarios where the immune infiltration is heterogeneous that some areas of the patient's tumour have high numbers of TILs while other areas completely lack them. This spontaneous presentation of a heterogeneous immune infiltration could be a great opportunity to study why some tumours present TILs at diagnosis but others do not, while eliminating inter patient's differences.

Methods

In this study, we have identified five TNBC patie

SUBMITTER: Quintana A 

PROVIDER: S-EPMC10196631 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature