Comparative analysis reveals epigenomic evolution related to species traits and genomic imprinting in mammals.

ABSTRACT: DNA methylation is an epigenetic modification that plays a crucial role in various regulatory processes, including gene expression regulation, transposable element repression, and genomic imprinting. However, most studies on DNA methylation have been conducted in humans and other model species, whereas the dynamics of DNA methylation across mammals remain poorly explored, limiting our understanding of epigenomic evolution in mammals and the evolutionary impacts of conserved and lineage-specific DNA methylation. Here, we generated and gathered comparative epigenomic data from 13 mammalian species, including two marsupial species, to demonstrate that DNA methylation plays critical roles in several aspects of gene evolution and species trait evolution. We found that the species-specific DNA m

SUBMITTER: Hu Y 

PROVIDER: S-EPMC10196708 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature