Anti‑tumor effects of an aqueous extract of Ecklonia cava in BALB/cKorl syngeneic mice using colon carcinoma CT26 cells.

ABSTRACT: Ecklonia cava (E. cava) is well known as one of edible alga that contains various unique polyphenols. The anti‑tumor activity of an aqueous extract of E. cava (AEC) against colon carcinoma was evaluated by analyzing the alterations in tumor growth, histopathological structure and molecular mechanisms in CT26 tumor‑bearing BALB/cKorl syngeneic mice after administrating AEC for five weeks. AEC contained high total phenolic contents and demonstrated significant scavenging activity against 2,2‑diphenyl‑1‑picrylhydrazyl radicals. Marked anti‑tumor effects were demonstrated in the AEC‑treated CT26 cells. In the in vivo syngeneic model, the AEC treatment decreased the volume and weight of CT26 tumors, and expanded the necrotic region in the hematoxylin and eosin staine

SUBMITTER: Gong JE 

PROVIDER: S-EPMC10196738 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature