In vivo synaptic density loss correlates with impaired functional and related structural connectivity in Alzheimer's disease.

ABSTRACT: Synapse loss has been considered as a major pathological change in Alzheimer's disease (AD). It remains unclear about whether and how synapse loss relates to functional and structural connectivity dysfunction in AD. We measured synaptic vesicle glycoprotein 2 A (SV2A) binding using ¹⁸F-SynVesT-1 PET to evaluate synaptic alterations in 33 participants with AD, 31 with mild cognitive impairment (MCI), and 30 controls. We examined the correlation between synaptic density and cognitive function. Functional MRI was performed to analyze functional connectivity in lower synaptic density regions. We tracked the white matter tracts between impaired functional connectivity regions using Diffusion MRI. In AD group, lower synaptic density in bilateral cortex and hippocampus was found when c

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10196742 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature