Medical therapy after surgical aortic valve replacement for aortic regurgitation.

ABSTRACT:

Objectives

Current clinical guidelines have no specific recommendations regarding medical therapy after surgical aortic valve replacement in patients with aortic regurgitation (AR). We studied the association between medical therapy with renin-angiotensin system (RAS) inhibitors, statins and β-blockers and long-term major adverse cardiovascular events.

Methods

All patients undergoing valve replacement due to AR between 2006 and 2017 in Sweden and alive 6 months after discharge were included. Time-dependent multivariable Cox regression models adjusted for age, sex, patient characteristics, comorbidities, other medications and year of surgical aortic valve replacement were used. Primary outcome was a composite of all-cause mortality, myocardial infarction and stroke. Subgroup

SUBMITTER: Torngren C 

PROVIDER: S-EPMC10196817 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature