A strategy of local hydrogen capture and catalytic hydrogenation for enhanced therapy of chronic liver diseases.

ABSTRACT: Background: Chronic liver diseases (CLD) frequently derive from hepatic steatosis, inflammation and fibrosis, and become a leading inducement of cirrhosis and hepatocarcinoma. Molecular hydrogen (H₂) is an emerging wide-spectrum anti-inflammatory molecule which is able to improve hepatic inflammation and metabolic dysfunction, and holds obvious advantages in biosafety over traditional anti-CLD drugs, but existing H₂ administration routes cannot realize the liver-targeted high-dose delivery of H₂, severely limiting its anti-CLD efficacy. Method: In this work, a concept of local hydrogen capture and catalytic hydroxyl radical (·OH) hydrogenation is proposed for CLD treatment. The mild and moderate non-alcoholic steatohepatitis (NASH) model mice

SUBMITTER: Tao G 

PROVIDER: S-EPMC10196827 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature