Development and validation of a prognostic 15-gene signature for stratifying HER2+/ER+ breast cancer.

ABSTRACT:

Background

Human epidermal growth receptor 2-positive (HER2+) breast cancer (BC) is a heterogeneous subgroup. Estrogen receptor (ER) status is emerging as a predictive marker within HER2+ BCs, with the HER2+/ER+ cases usually having better survival in the first 5 years after diagnosis but have higher recurrence risk after 5 years compared to HER2+/ER-. This is possibly because sustained ER signaling in HER2+ BCs helps escape the HER2 blockade. Currently HER2+/ER+ BC is understudied and lacks biomarkers. Thus, a better understanding of the underlying molecular diversity is important to find new therapy targets for HER2+/ER+ BCs.

Methods

In this study, we performed unsupervised consensus clustering together with genome-wide Cox regression analyses on the gene expression data o

SUBMITTER: Liu Q 

PROVIDER: S-EPMC10196919 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature